SOD1 — Superoxide dismutase 1

SOD1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SOD1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	mRNA splicing factors RNA processing	CALM1, CALM2, CKS2, CYCS, EIF4A3, HNRNPA0, HNRNPA2B1, HNRNPAB +12 more	View in SCUBA
CD4⁺ T cells	Chaperone Proteostasis Protein processing & ER	BANF1, CCT3, CCT4, CCT5, FXR1, HNRNPH3, HSPB1, MAGOH +7 more	View in SCUBA
Enterocytes	Core energy metabolism Mitochondrial & OxPhos	ACAA2, CFL1, CYCS, GAPDH, ME2, P4HB, PPA1, PSME2	View in SCUBA
Fibroblasts	Translation Initiation Housekeeping	CCNI, CD99, CNBP, EIF3E, EIF3F, ESD, HNRNPA1, ITM2B +3 more	View in SCUBA
Gamma-delta T cells	ER/Osmotic Stress Stress	ABHD3, DNAJA4, FKBP4, HIBCH, HSD17B7, HSPA4, HSPB1, MBNL2 +7 more
Glial cells	Antioxidant Stress Response Stress	AP2S1, CSTB, DYNLRB1, HSBP1, MAGED2, NDUFB11, PLPP1, PPDPF +1 more	View in SCUBA
Innate lymphoid cells	Proteostasis Stress Response Stress	BUB3, ERP29, GABARAPL2, HIGD2A, NCOR1, NPM1, POLR1D, ST13 +2 more	View in SCUBA
Macrophages	Protein Homeostasis Mixed Housekeeping	ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more	View in SCUBA
Monocytes	Autophagy Metabolic Stress Stress	ACKR3, AFMID, DPEP2, EAF2, GPBAR1, NAP1L1, PKP2, SPATA6 +1 more	View in SCUBA
Smooth muscle cells	Basal Maintenance Genes Housekeeping	ANAPC16, C1QTNF2, C7orf50, CCNI, COX14, COX8A, HNRNPA1, MRPL33 +3 more	View in SCUBA

About the gene

Synonyms	ALS, ALS1, IPOA
Chromosome	21: 31659666-31668931
Predicted location	Intracellular
Essential gene	Yes
Protein class	Cancer-related genes, Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Antioxidant, Oxidoreductase

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.