ACKR3 — Atypical chemokine receptor 3
ACKR3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACKR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1, GABRE +15 more | View in SCUBA |
| Fibroblasts | NFAT-cAMP Signaling Inflammatory | ADGRE2, ANKRD28, CHSY1, CREM, ELL2, FRMD4A, GPCPD1, RCAN1 +3 more | View in SCUBA |
| Monocytes | Autophagy Metabolic Stress Stress | AFMID, DPEP2, EAF2, GPBAR1, NAP1L1, PKP2, SOD1, SPATA6 +1 more | View in SCUBA |
| Smooth muscle cells | Notch-TGFbeta Signaling Development | AFAP1L2, CSRNP3, GJC1, HTR1F, JAG1, LRRC10B, RAP2A, SLC38A11 +3 more | View in SCUBA |
About the gene
| Synonyms | CMKOR1, CXCR7, GPR159, RDC1 |
|---|---|
| Chromosome | 2: 236567787-236582354 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins |
| Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
| Biological process | Cell adhesion, Host-virus interaction |
Function
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels. (Microbial infection) Acts as a coreceptor with CXCR4 for a restricted number of HIV isolates
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.