Autophagy Metabolic Stress
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include ULK2 (autophagy-initiating kinase), SOD1 (superoxide dismutase, oxidative stress defense), AFMID (arylformamidase, kynurenine/tryptophan catabolism pathway), GPBAR1 (bile acid receptor with immunomodulatory roles), and ACKR3 (atypical chemokine receptor). The module combines autophagy induction (ULK2), oxidative stress response (SOD1), and immunometabolic signaling (AFMID kynurenine pathway, GPBAR1 bile acid sensing). Upregulated in both UC and CD inflammation. PKP2 and SPATA6 are less clearly linked. The dominant theme is metabolic/autophagic stress adaptation in inflammatory monocytes.
Genes
ACKR3, AFMID, DPEP2, EAF2, GPBAR1, NAP1L1, PKP2, SOD1, SPATA6, ULK2
Most correlated modules
- Non-classical Monocyte · correlation 0.91
- Macrophage Differentiation · correlation 0.80
- Biosynthetic Metabolic Activation · correlation 0.78
- Non-classical Monocyte State · correlation 0.76
- Mitochondrial Immune Regulation · correlation 0.75
- Non-classical Monocyte · correlation 0.73
- Tissue Macrophage Identity · correlation 0.72
- Non-classical Monocyte Migration · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.