AKT1S1 — AKT1 substrate 1
AKT1S1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKT1S1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17/MAIT type-17 Th17 fate | CA10, CA2, CCL20, CEBPD, GFPT2, IL22, IL4I1, LRRN3 +9 more | View in SCUBA |
| Innate lymphoid cells | ILC3 Transcriptional Identity Differentiation | ABHD5, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1, HEXIM1 +12 more | View in SCUBA |
About the gene
| Synonyms | Lobe, MGC2865, PRAS40 |
|---|---|
| Chromosome | 19: 49869033-49878459 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate- recruitment site. In response to insulin and nutrients, AKT1S1 dissociates from mTORC1. Its activity is dependent on its phosphorylation state and binding to 14-3-3. May also play a role in nerve growth factor-mediated neuroprotection (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.