ILC3 Transcriptional Identity
Gene co-expression module in Innate lymphoid cells
| Category | Differentiation |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module is heterogeneous. HES1 (Notch target, 8.3x ILC3-enriched) and EGR3 (7.9x ILC3-enriched) are ILC3-specific transcription factors. GADD45B and IER5 are stress/immediate-early genes. ODC1 and SAT1 represent polyamine metabolism. HEXIM1 inhibits P-TEFb/transcription elongation. CKS2 and SERTAD1 relate to cell cycle. The dominant ILC3-specific transcription factor signature (HES1, EGR3) combined with stress genes suggests this module captures ILC3-specific transcriptional identity under inflammatory conditions, though it is mixed.
Genes
ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1, HEXIM1, HIC1, IER5, IER5L, IVNS1ABP, MARCKSL1, NEU1, ODC1, PNP, RRAD, SAT1, SERTAD1, TUBB4B
Most correlated modules
- Immediate Early Response · correlation 0.95
- Transcriptional Activation · correlation 0.90
- mTOR Stress Response · correlation 0.90
- Heat Shock Response · correlation 0.89
- NK Cytokine Signaling · correlation 0.89
- Dissociation Stress Response · correlation 0.86
- Integrated Stress Response · correlation 0.81
- NF-κB Inflammatory Activation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.