ARF4 — ADP ribosylation factor 4

ARF4 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ARF4's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Unfolded Protein Response Protein processing & ER	ATF4, DUSP8, HSPA5, IL23A, NLRP3, NOP56, NRIP3, NXT1 +7 more	View in SCUBA
Endothelial	Stress RNA Processing RNA processing & translation	CACYBP, ELOC, ENY2, EWSR1, GNA14, HNRNPDL, HNRNPF, MAP3K13 +5 more	View in SCUBA
Fibroblasts	ER Stress UPR Stress	B4GALT1, BTG3, BZW1, CYCS, EFHD2, ELOC, LDHA, LITAF +6 more	View in SCUBA
Glial cells	ER Stress Response Stress	ANXA1, CSNK1A1, HSPA5, KRT10, RAB32, RBM3, SERP1, SET +4 more	View in SCUBA
Goblet cells	ERAD ER Homeostasis Protein processing & ER	ATP2A2, C1orf122, DNAJB9, HERPUD1, JTB, LARP1B, PGM3, SELENOK +1 more	View in SCUBA
Innate lymphoid cells	ILC3 Transcriptional Identity Differentiation	ABHD5, AKT1S1, ATP1A1, CKS2, EGR3, GADD45B, HES1, HEXIM1 +12 more	View in SCUBA
Macrophages	RAS-MAPK Signaling Housekeeping	ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1, JAK1 +26 more	View in SCUBA
Mucosal-associated invariant T cell	Apoptosis Regulation Immune regulation	ARRDC3, CARD8, CFLAR, CREBZF, MAPRE2, NABP1, PCF11, PPP1R10 +1 more
Natural Killer cells	ER Stress Response Stress	CYCS, DNAJB6, EIF4A3, EIF5, GADD45B, HERPUD1, SAP18, SERTAD1	View in SCUBA
Pericytes	ER Stress Response Stress	HSPA5, LDHA, PDLIM1, RAP1B, REXO2, SEC61G, SELENOS, SNX6	View in SCUBA
Smooth muscle cells	ER Secretory Trafficking Protein processing & ER	DEGS1, GYPC, P4HB, PDIA6, SH3PXD2A, SSR3, TMED9, TMEM123	View in SCUBA

About the gene

Synonyms	ARF2
Chromosome	3: 57571363-57598220
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Biological process	ER-Golgi transport, Protein transport, Transport

Function

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.