GADD45B — Growth arrest and DNA damage inducible beta

GADD45B belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GADD45B's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate early response Stress	ABHD5, CEBPB, CITED2, FAM53C, GADD45A, HEXIM1, HSPA2, IER5L +9 more	View in SCUBA
CD4⁺ T cells	Pol II Transcription Regulation DNA/chromatin regulation	ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more	View in SCUBA
CD8⁺ T cells	Immediate Early Response Stress	ARRDC3, ATF3, CLK1, EIF4A2, EIF5, IER5, JUN, KLF6 +6 more	View in SCUBA
Fibroblasts	Heat Shock Response Stress	BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, HSPH1, IER5, MIDN +5 more	View in SCUBA
Gamma-delta T cells	AP-1 Immediate Early Response Stress	BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, HEXIM1 +25 more
Glial cells	DNA Damage Response Stress	BRD2, FAM53C, IER5, ING1, NFKBIZ, PABPC1, SRSF3, TUBB4B +1 more	View in SCUBA
Innate lymphoid cells	ILC3 Transcriptional Identity Differentiation	ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, HES1, HEXIM1 +12 more	View in SCUBA
Lymphatic endothelial	Lymphatic Valve Formation Valve formation	CCN1, CCN2, DUSP2, FOXC1, GADD45G, GATA2, HES5, HSPA2 +9 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	AMD1, BRD2, CITED2, CSKMT, FUS, GADD45G, H2AX, HEXIM1 +17 more
Natural Killer cells	ER Stress Response Stress	ARF4, CYCS, DNAJB6, EIF4A3, EIF5, HERPUD1, SAP18, SERTAD1	View in SCUBA
Neutrophils	Chemokine Secretion Cytokine & chemokine secretion	CXCL1, CXCL2, CXCL8, DDIT3, GLUL, HCAR2, IER5, MAFF +3 more
Smooth muscle cells	Immediate Early Response Stress	ATF3, BTG1, BTG2, CDKN1A, EGR1, FOS, HES1, IER2 +7 more	View in SCUBA

About the gene

Synonyms	DKFZP566B133, GADD45BETA, MYD118
Chromosome	19: 2476122-2478259
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Developmental protein
Biological process	Apoptosis, Differentiation

Function

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.