EGR3 — Early growth response 3

EGR3 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EGR3's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate Early NFkB BCR/AP1/NFKb pathway	ARL5B, CDKN1A, CSRNP1, DUSP2, EGR1, IER2, NFKBIA, PPP1R15B +3 more	View in SCUBA
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ADRA2B, CD83, CHD4, CYB5D1, DUSP2, EGR2, EGR4, FOSL1 +9 more	View in SCUBA
Fibroblasts	NF-κB Stress Response Inflammatory	NAMPT, NCOA7, NFIL3, PHLDA1, PHLDA2, SAT1, SLC20A1, SOD2 +3 more	View in SCUBA
Glial cells	Integrated Stress Response Stress	ANKRD37, BAG3, CDKN1A, CSRNP1, DDIT3, EGR2, MCL1, MIDN +3 more	View in SCUBA
Goblet cells	NF-κB Stress Response Stress	ATF3, CCNL1, IER3, MAFF, MYADM, NFKBIA, NR4A1, RHOB +1 more	View in SCUBA
Innate lymphoid cells	ILC3 Transcriptional Identity Differentiation	ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, GADD45B, HES1, HEXIM1 +12 more	View in SCUBA
Macrophages	NF-κB Effector Response Inflammatory	ARL5B, BIRC3, CYB5D1, DUSP2, HES1, ICAM4, PTGS2, SIK1	View in SCUBA
Monocytes	TNF/IL-1 Cytokine Storm Inflammatory	CCL3, CCL4, CCL4L2, IL1A, IL6, KCNJ2, PTGS2, TNF +3 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Effector Activation Inflammation	ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10 +10 more
Natural Killer cells	EGR2/3 NK Activation activation	AMD1, CHD4, CRTAM, CSF2, DNAJB9, EGR2, GADD45A, MAP2K3 +4 more	View in SCUBA
Neutrophils	Inflammasome IL-1 Response Cytokine & chemokine secretion	CSRNP1, G0S2, IER3, IFRD1, IL1B, IL1RN, IVNS1ABP, LPCAT1 +5 more
Smooth muscle cells	Immediate Early Response Stress	ABHD5, ARC, ARL5B, BRD2, DDIT3, GDF11, HEXIM1, IER5 +4 more	View in SCUBA

About the gene

Synonyms	PILOT
Chromosome	8: 22687659-22693480
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Function

Probable transcription factor involved in muscle spindle development

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.