AP1S3 — Adaptor related protein complex 1 subunit sigma 3
AP1S3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AP1S3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Leukocyte Migration Signaling migration & adhesion | ARID5B, ATP2B1, CYBB, DOCK8, EMB, GLIPR1, IQGAP1, KDM2A +5 more | View in SCUBA |
About the gene
| Synonyms | sigma1C |
|---|---|
| Chromosome | 2: 223667680-223838027 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.