KDM2A — Lysine demethylase 2A
KDM2A belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KDM2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Leukocyte Migration Signaling migration & adhesion | AP1S3, ARID5B, ATP2B1, CYBB, DOCK8, EMB, GLIPR1, IQGAP1 +5 more | View in SCUBA |
| CD4⁺ T cells | Chromatin transcription regulation DNA/chromatin regulation | ADAM10, CIRBP, CLIP1, CUL9, GRPEL2, HBP1, NCOA3, NSD3 +10 more | View in SCUBA |
| Gamma-delta T cells | MAPK Kinase Signaling TCR Signaling | ARIH1, B4GALT1, BRAF, CDK16, CHD1, DYRK1A, GNA13, MAP3K2 +8 more | |
| Innate lymphoid cells | Cytoskeletal Remodeling Cytoskeleton & motility | BCLAF1, BPTF, CBL, CDK13, IQGAP2, KDM5A, LTC4S, MACF1 +8 more | View in SCUBA |
| Macrophages | Epigenetic Remodeling Housekeeping | AFF4, AGO3, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, EPC1 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Processing Stress RNA processing & translation | DDX3X, ETV3, HSPA5, IVNS1ABP, NAF1, RALGAPA1, SFPQ, SLC2A3 +3 more | |
| Neutrophils | Actin Cytoskeletal Remodeling Cytoskeletal | ACAP2, ARHGAP15, COP1, CUX1, DOCK8, DPYD, MED13L, MKLN1 +9 more |
About the gene
| Synonyms | CXXC8, DKFZP434M1735, FBL11, FBL7, FBXL11, FLJ00115, JHDM1A, KIAA1004, LILINA |
|---|---|
| Chromosome | 11: 67119263-67258082 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, Dioxygenase, DNA-binding, Oxidoreductase, Repressor |
| Biological process | Biological rhythms, Transcription, Transcription regulation, Ubl conjugation pathway |
Function
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically- independent manner.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.