CYBB — Cytochrome b-245 beta chain
CYBB belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYBB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Leukocyte Migration Signaling migration & adhesion | AP1S3, ARID5B, ATP2B1, DOCK8, EMB, GLIPR1, IQGAP1, KDM2A +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Myeloid Innate Immune Myeloid development | CCR2, CUX2, FXYD7, KCNC3, KIF17, NFKB1, PLD4, RNASE6 +5 more | |
| Macrophages | Myeloid Innate Signaling Innate immunity | ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC +34 more | View in SCUBA |
| Neutrophils | Secondary Granule Antibacterial Degranulation | CAMP, CHI3L1, CHIT1, CRISP3, HP, LCN2, LTF, MMP8 +3 more |
About the gene
| Synonyms | CGD, GP91-PHOX, NOX2 |
|---|---|
| Chromosome | X: 37780018-37813461 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Ion channel, Oxidoreductase, Voltage-gated channel |
| Biological process | Electron transport, Ion transport, Transport |
Function
Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (Probable). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). NADPH oxidase complex assembly is impaired through interaction with NRROS (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.