ARID5B — AT-rich interaction domain 5B

ARID5B belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ARID5B's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Leukocyte Migration Signaling migration & adhesion	AP1S3, ATP2B1, CYBB, DOCK8, EMB, GLIPR1, IQGAP1, KDM2A +5 more	View in SCUBA
CD4⁺ T cells	mRNA stability regulation Immune regulation	APLP2, CARHSP1, GK, GLCCI1, GRAMD4, HIVEP1, METTL8, MPG +12 more	View in SCUBA
CD8⁺ T cells	T cell Immune Tolerance Immune regulation	CBLB, DTHD1, LYST, NAMPT, STAT3, TNFRSF1B, TRAF5	View in SCUBA
Enterocytes	Epithelial polarity cytoskeleton Cytoskeletal	ARHGEF10L, CADPS2, CLMN, DGKH, FAR2, LLGL2, PLEKHA5, PLEKHG1 +3 more	View in SCUBA
Fibroblasts	OSM Cytokine Response Inflammatory	ELK3, FGF7, OSMR, PDE4B, PTGER1, RNF145, UFM1	View in SCUBA
Hematopoietic progenitor cells	Early Myeloid Progenitor Myeloid development	ABCA13, CD34, GPRIN3, NCOA7, PRSS2, RXFP1, SETBP1
Macrophages	Alternative Activation Lipid Lipid metabolism	ACSL1, ADCY3, AGFG1, ARHGEF10L, ATP2B4, BCL6, CCL13, CD55 +24 more	View in SCUBA
Monocytes	Inflammasome Activation Innate immunity	AIM2, APOBEC3G, BATF3, BST2, CASP5, CD47, CNDP2, CYSTM1 +4 more	View in SCUBA
Mucosal-associated invariant T cell	Naive T cell T cell maturation	AK5, BACH2, CCR7, CSGALNACT1, FHIT, FOXP1, LEF1, MAL +6 more
Pericytes	Quiescent Pericyte State Developmental	C1QTNF1, CPE, HOPX, ITGA7, LPP, MT2A, MTHFD2, SLIT3 +1 more	View in SCUBA

About the gene

Synonyms	FLJ21150, MRF2
Chromosome	10: 61901684-62096944
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Function

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.