Leukocyte Migration Signaling
Gene co-expression module in CD19⁺ B cells
| Category | migration & adhesion |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include DOCK8 (B/T cell migration and immune synapse), IQGAP1 (cytoskeletal scaffold), PRKCB (BCR signaling), CYBB (NADPH oxidase), ATP2B1 (calcium pump), and ARID5B. The combination of DOCK8, IQGAP1, ATP2B1, PRKCB suggests a leukocyte signaling/cytoskeletal-migration program in B cells. DOCK8 and IQGAP1 are strong cytoskeletal/migration regulators; PRKCB links to BCR signaling. The mixed leukocyte activation/migration signature is best captured as immune cell migration & adhesion.
Genes
AP1S3, ARID5B, ATP2B1, CYBB, DOCK8, EMB, GLIPR1, IQGAP1, KDM2A, PBXIP1, PRKCB, RTN4, TOR3A, UPF2
Most correlated modules
- BCR Signaling Regulation · correlation 0.92
- Chromatin Modification · correlation 0.88
- B-cell signaling regulators · correlation 0.85
- Chromatin modifiers · correlation 0.79
- B Cell Identity Signaling · correlation 0.78
- B cell activation · correlation 0.73
- B-cell activation · correlation 0.73
- TNF/NF-kB response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.