APOBEC3A — Apolipoprotein B mRNA editing enzyme catalytic subunit 3A
APOBEC3A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APOBEC3A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | Interferon Stimulated Genes Antiviral | ADAM8, BCL3, DDX60L, GBP2, MEFV, MIDN, MKNK2, MX2 +1 more |
About the gene
| Synonyms | ARP3, PHRBN |
|---|---|
| Chromosome | 22: 38952741-38992778 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Antiviral defense, Immunity, Innate immunity |
Function
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.