MIDN — Midnolin

MIDN belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MIDN's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Integrated Stress Response Stress	AMD1, DDIT3, FAM133B, GOLGB1, IFRD1, MKNK2, PHF1, PIM2 +4 more	View in SCUBA
CD4⁺ T cells	Pol II Transcription Regulation DNA/chromatin regulation	ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DNAJB1, DUSP1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A +11 more	View in SCUBA
Fibroblasts	Heat Shock Response Stress	BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, IER5 +5 more	View in SCUBA
Gamma-delta T cells	Anabolic Activation Response Housekeeping	ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more
Glial cells	Integrated Stress Response Stress	ANKRD37, BAG3, CDKN1A, CSRNP1, DDIT3, EGR2, EGR3, MCL1 +3 more	View in SCUBA
Goblet cells	Goblet Cell Differentiation Epithelial development	CLDN4, EIF1, ELF3, KLF3, KLF4, PPP1R15A, RAB11FIP1, TOB1	View in SCUBA
Innate lymphoid cells	mTOR Stress Response Stress	CEBPB, DDIT3, DDIT4, GLS, ID1, IFRD1, INTS6, JMJD6 +9 more	View in SCUBA
Lymphatic endothelial	Stress Granule Assembly Stress	AMD1, BHLHE40, CD55, CDKN1A, DDX3X, DUSP5, EIF4G2, ERF +3 more	View in SCUBA
Macrophages	Macrophage Lipid Sensing Lipid metabolism	ARL4A, ARL4C, BIRC2, CES2, DDX21, DDX24, DDX27, GPR183 +12 more	View in SCUBA
Monocytes	AMPK-FOXO Stress Response Stress	AHCTF1, C15orf39, FOXO3, FURIN, IRF2BP2, JARID2, PRKAG2, TLE3	View in SCUBA
Mucosal-associated invariant T cell	ER Stress UPR Stress	DDIT3, DNAJB9, EIF4A1, GTF2B, HERPUD1, HNRNPA0, IDI1, LDHA +9 more
Natural Killer cells	EGR2/3 NK Activation activation	AMD1, CHD4, CRTAM, CSF2, DNAJB9, EGR2, EGR3, GADD45A +4 more	View in SCUBA
Neutrophils	Interferon Stimulated Genes Antiviral	ADAM8, APOBEC3A, BCL3, DDX60L, GBP2, MEFV, MKNK2, MX2 +1 more
Pericytes	Vascular Quiescence Developmental	HBEGF, ID2, KLF2, KLF4, MYLIP, PLK2, RHOB, SAT1 +1 more	View in SCUBA
Smooth muscle cells	NF-kB Stress Response Stress	BHLHE40, CCNL1, FADS3, HSP90AB1, IER3, NFKBIZ, PPP1R15A, THBS1 +1 more	View in SCUBA

About the gene

Synonyms	Stx
Chromosome	19: 1248553-1259143
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins

Function

Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation. Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.