MX2 — MX dynamin like GTPase 2
MX2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MX2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Type I Interferon Anti-viral | GBP2, GBP4, IRF9, ISG15, ISG20, LY6E, MNDA, MX1 +9 more | View in SCUBA |
| CD4⁺ T cells | Metabolic reprogramming Housekeeping | ATG16L2, ATP1A1, CCNYL1, CSKMT, EIF1AY, FAM241A, HMGCS1, ING1 +12 more | View in SCUBA |
| CD8⁺ T cells | Antiviral ISG Response Inflammation | CMPK2, HELZ2, HERC5, IFIT1, IFIT3, ISG20, NT5C3A, PPM1K +1 more | View in SCUBA |
| Endothelial | Type I Interferon Inflammation | CMPK2, HELZ2, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3 +9 more | View in SCUBA |
| Fibroblasts | Type I Interferon Inflammatory | APOL6, BATF2, CXCL10, GBP1, IFI44L, IFIT2, IFIT3, ISG15 +6 more | View in SCUBA |
| Macrophages | Type I Interferon Antiviral | CCL8, CMPK2, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT1 +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | CMPK2, HELZ2, HERC6, IFIT1, LAMP3, LGALS9, OAS3, PLSCR1 +2 more | |
| Neutrophils | Interferon Stimulated Genes Antiviral | ADAM8, APOBEC3A, BCL3, DDX60L, GBP2, MEFV, MIDN, MKNK2 +1 more |
About the gene
| Synonyms | MXB |
|---|---|
| Chromosome | 21: 41361999-41409393 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Antiviral defense, Immunity, Innate immunity, mRNA transport, Protein transport, Translocation, Transport |
Function
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.