ADAM8 — ADAM metallopeptidase domain 8
ADAM8 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAM8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2, ITGA1 +13 more | View in SCUBA |
| Gamma-delta T cells | Effector Cell Migration migration & adhesion | ADAM15, ANXA2, APOBEC3G, CD52, CTSC, DSTN, FUT11, GLIPR2 +17 more | |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ACTN1, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9, DRAM1 +21 more | View in SCUBA |
| Monocytes | Inflammatory Metabolic Reprogramming Inflammatory | ACTN1, DGAT2, EAF1, GPAT3, MCTP2, PTPN7, SLC25A37, SLC2A3 | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Remodeling Migration migration & adhesion | BIN2, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2, CYB561 +14 more | |
| Neutrophils | Interferon Stimulated Genes Antiviral | APOBEC3A, BCL3, DDX60L, GBP2, MEFV, MIDN, MKNK2, MX2 +1 more |
About the gene
| Synonyms | CD156, CD156A, MS2 |
|---|---|
| Chromosome | 10: 133262420-133276868 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
Possible involvement in extravasation of leukocytes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.