Interferon Stimulated Genes
Gene co-expression module in Neutrophils
| Category | Antiviral |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub genes MX2 (antiviral dynamin GTPase), DDX60L (antiviral RNA helicase), GBP2 (guanylate-binding protein, IFN-induced), and APOBEC3A (cytidine deaminase with antiviral/restriction activity) are canonical type I/II interferon-stimulated genes. MEFV (pyrin, inflammasome), BCL3 (NF-κB regulator), PROK2 (neutrophil chemoattractant), ADAM8 (metalloprotease in neutrophil activation), and MIDN (midnolin, stress response) add inflammatory activation context. MKNK2 phosphorylates eIF4E downstream of innate signaling. The dominant theme is interferon-stimulated gene (ISG) expression in neutrophils. Neighbor context: sits near M65 (TLR/innate) and M38 (ISG/antiviral), confirming an interferon-driven inflammatory neighborhood.
Genes
ADAM8, APOBEC3A, BCL3, DDX60L, GBP2, MEFV, MIDN, MKNK2, MX2, PROK2
Most correlated modules
- Bacterial Phagocytosis Program · correlation 0.88
- Myeloid Inflammatory Activation · correlation 0.85
- TLR Lipid Signaling · correlation 0.80
- C5aR Complement Activation · correlation 0.79
- Neutrophil Chemotaxis Receptors · correlation 0.75
- Innate DNA Sensing ISG · correlation 0.75
- Myeloid Identity · correlation 0.67
- KLF2 Survival Response · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.