BCL3 — BCL3 transcription coactivator

BCL3 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

BCL3's module in each cell type

Cell type	Module	Shares the module with
Endothelial	NF-κB Early Response Inflammation	BHLHE40, ICAM1, INSIG1, ITPKC, KLF10, LDLR, MYADM, RND1 +3 more	View in SCUBA
Fibroblasts	NF-κB Epigenetic Reprogramming Inflammatory	BTG2, CDKN1A, CSRNP1, DUSP5, EGR2, KDM6B, KLF10, LDLR +3 more	View in SCUBA
Gamma-delta T cells	Late Activation Autophagy Immune regulation	BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1, IRF2BP2 +19 more
Glial cells	COX-2/NF-κB Inflammation Inflammation	ABL2, ARID5A, EMP1, LMNA, PDLIM3, PHLDA1, PTGS2	View in SCUBA
Lymphatic endothelial	NF-κB Inflammatory Activation Inflammation	CD83, HIF1A, INSIG1, IPO7, IRF1, KDM6B, MAP3K8, NFKBIZ +1 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD, DNAJB6 +33 more	View in SCUBA
Monocytes	Non-canonical NF-κB Innate immunity	AMPD2, BEST1, DENND5A, FAM20A, NFKB2, NOCT, RELB, TICAM1	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Activation Immune regulation	FURIN, GTF3C1, IRAK1, IRS2, ISCA1, PITHD1, PRELID3B, RABGGTB +3 more
Natural Killer cells	NF-κB Activation Inflammation	ADGRE5, BHLHE40, CSRNP1, DUSP10, NFKB1, NFKB2, NINJ1, OTULIN +3 more	View in SCUBA
Neutrophils	Interferon Stimulated Genes Antiviral	ADAM8, APOBEC3A, DDX60L, GBP2, MEFV, MIDN, MKNK2, MX2 +1 more
Pericytes	NF-κB Inflammatory Response Inflammatory	ABL2, ADAMTS9, ARL4A, BHLHE40, FOSL2, ICAM1, KLF10, PIM3 +3 more	View in SCUBA

About the gene

Synonyms	BCL4, D19S37
Chromosome	19: 44747705-44760044
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Molecular function	Activator
Biological process	Transcription, Transcription regulation

Function

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.