BAD — BCL2 associated agonist of cell death
BAD belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BAD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Mitochondrial Maintenance Mitochondrial & OxPhos | ADGRG1, ATP23, DNTTIP2, ETFB, FUBP1, ICAM3, LRIG3, MDM2 +9 more | View in SCUBA |
About the gene
| Synonyms | BBC2, BCL2L8 |
|---|---|
| Chromosome | 11: 64269830-64284704 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, RAS pathway related proteins |
| Biological process | Apoptosis |
Function
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.