Mitochondrial Maintenance
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 18 genes have a known function matching the annotation |
Why this annotation
Multiple mitochondrial hub genes: SURF1 (complex IV assembly factor), ETFB (electron transfer flavoprotein beta, fatty acid oxidation), MRPL34 (mitoribosomal protein), ATP23 (mitochondrial inner membrane protease), PMPCA (mitochondrial processing peptidase). NUDT9 (ADP-ribose hydrolase, mitochondria-associated). MDM2 and BAD add apoptosis context. SDSL (serine catabolism) and PMVK (mevalonate pathway) are metabolic. Module decreases with inflammation and recovers with treatment, consistent with mitochondrial dysfunction in IBD. Neighbor M37 (ribosome biogenesis) and M85 (splicing) suggest a neighborhood of general cellular maintenance programs.
Genes
Most correlated modules
- Ribosome Biogenesis · correlation 0.92
- Mitochondrial Ribosome · correlation 0.92
- Vesicular Trafficking · correlation 0.86
- ER Stress & UPR · correlation 0.86
- Ubiquitin-Proteasome System · correlation 0.84
- Stem Cell Epigenetic · correlation 0.81
- RNA Splicing Regulation · correlation 0.79
- BEST4 Colonocyte Identity · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.