ADGRG1 — Adhesion G protein-coupled receptor G1
ADGRG1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADGRG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ATP8B4, CCL3, CCL4, CCL4L2, CSF2, FASLG, GNLY, GZMB +10 more | View in SCUBA |
| CD8⁺ T cells | TCR Activation & Modulation Exhaustion | AKAP5, CTLA4, ENTPD1, ETV1, GALNT2, LAYN, MAST4, SOX4 | View in SCUBA |
| Endothelial | Endothelial Lipid Signaling migration & adhesion | A2M, ARHGEF15, CNOT6L, CYYR1, DIP2B, HIP1R, PCDH1, PITPNC1 +3 more | View in SCUBA |
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | ANXA4, CADM1, CX3CR1, FCGR3A, FGFBP2, FGL2, GNLY, GZMB +14 more | |
| Natural Killer cells | Cytotoxic NK Maturation Cytotoxicity | AKR1C3, CXCR2, FCGR3A, FGFBP2, GK5, LGR6, MTSS1, PRF1 +4 more | View in SCUBA |
| Pericytes | Angiogenic Receptor Signaling Developmental | CPLX1, EPHB4, KDR, MGAT4A, PLXNA2, RASGRP3, ROBO4, SLCO2A1 +1 more | View in SCUBA |
About the gene
| Synonyms | GPR56, TM7LN4, TM7XN1 |
|---|---|
| Chromosome | 16: 57610652-57665580 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Developmental protein, G-protein coupled receptor, Heparin-binding, Receptor, Transducer |
| Biological process | Cell adhesion, Differentiation, Neurogenesis |
Function
Adhesion G-protein coupled receptor (aGPCR) for steroid hormone 17alpha-hydroxypregnenolone (17-OH), which is involved in cell adhesion and cell-cell interactions. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway. ADGRG1 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases. Acts as a potent suppressor of ferroptosis: binding to 17-OH-binding initiates signaling that down- regulates CD36 and alleviates ferroptosis-induced liver injury (By similarity). Ligand-binding also induces cell adhesion activity via association with proteins such as collagen III/COL3A1 and TGM2 (By similarity). Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells (By similarity). Involved in cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination: association with COL3A1 in the developing brain inhibits neuronal migration via activation of the RhoA pathway. Together with TGM2, acts as a regulator of myelination and myelin repair in oligodendrocyte precursor cells (By similarity). Acts as a hemostatic sensor of shear force: G protein- coupled receptor signaling is activated in response to shear force in platelets, promoting G(13) G protein signaling, and platelet shape change and aggregation in a COL3A1-dependent manner. Acts as an inhibitor of VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA. Plays a role in the maintenance of hematopoietic stem cells in bone marrow niche (By similarity). Plays an essential role in testis development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.