ICAM3 — Intercellular adhesion molecule 3
ICAM3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ICAM3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | ARID5A, CD52, CD74, CD79A, CTSS, CYBA, HLA-DPA1, HLA-DPB1 +9 more | View in SCUBA |
| CD4⁺ T cells | Leukocyte adhesion signaling migration & adhesion | ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B +22 more | View in SCUBA |
| Gamma-delta T cells | Immune Synapse Cytoskeleton Cytoskeletal | ARHGAP4, ARHGAP45, ATP2A3, CD48, DDOST, IL32, LAPTM5, LTB4R2 +8 more | |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 more | View in SCUBA |
| Monocytes | Monocyte Innate Surveillance Innate immunity | CDKN2D, FCN1, MMP25, PADI2, RPH3A, S100P, TESC, TUBA4A | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Surface Signaling TCR Signaling | CD37, LIME1, MFNG, MZT2A, NAA10, PLSCR3, SIGIRR | |
| Neutrophils | Neutrophil Differentiation Developmental | ABTB1, FRAT2, GCA, MANSC1, MNDA, MSL3, NFE2, QPCT +2 more |
About the gene
| Synonyms | CD50, CDW50, ICAM-R |
|---|---|
| Chromosome | 19: 10333776-10339661 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Plasma proteins, Predicted membrane proteins |
| Biological process | Cell adhesion, Phagocytosis |
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha- L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.