BANP — BTG3 associated nuclear protein
BANP belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BANP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, CHD1, CHD2, ERCC6 +26 more | View in SCUBA |
About the gene
| Synonyms | BEND1, DKFZp761H172, FLJ10177, FLJ20538, SMAR1, SMARBP1 |
|---|---|
| Chromosome | 16: 87949244-88077318 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Developmental protein, DNA-binding, Repressor, RNA-binding |
| Biological process | Cell cycle, Transcription, Transcription regulation |
Function
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function (By similarity). Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity). Plays a role in the regulation of alternative splicing. Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.