CHD2 — Chromodomain helicase DNA binding protein 2
CHD2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Regulation DNA/chromatin regulation | AKAP9, ANKRD12, BBX, CHD7, IRF1, KDM7A, L3MBTL3, MAP3K1 +8 more | View in SCUBA |
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD6, CREBZF, DDX39B, DNASE1, EVI2B, FAM78A +21 more | View in SCUBA |
| Gamma-delta T cells | TCR Inhibitory Signaling Exhaustion | AFF4, CBLB, CCNH, CCNT1, CRYBG1, FYN, ISG20, PARP8 +9 more | |
| Innate lymphoid cells | Lymphocyte Apoptosis Regulation Immune regulation | ANP32B, ARMCX3, CCDC69, DHRS7, ELF1, FXYD5, GLIPR1, LEPROTL1 +14 more | View in SCUBA |
| Lymphatic endothelial | NF-κB Innate Signaling Inflammation | AKAP13, B4GALT5, BACH1, CNST, DENND5A, HIVEP1, HIVEP2, IRAK2 +11 more | View in SCUBA |
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, ERCC6 +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Signal Attenuation Immune regulation | AFF4, BORCS5, CENPC, CRACR2A, CRYBG1, DUSP16, FAS, FNBP1 +8 more |
About the gene
| Synonyms | DKFZp547I1315, DKFZp686E01200, DKFZp781D1727, FLJ38614 |
|---|---|
| Chromosome | 15: 92886203-93027996 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, DNA-binding, Hydrolase |
| Biological process | Myogenesis, Transcription, Transcription regulation |
Function
ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.