ATG2A — Autophagy related 2A
ATG2A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATG2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | ER Protein Translocation Protein processing & ER | BEST1, CLSTN1, CTDSP2, GALC, GSE1, HAPSTR1, HOOK2, KMT2E +12 more | |
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AGO2, AP1G1, ARFGAP3, BANP, CHD1, CHD2, ERCC6 +26 more | View in SCUBA |
| Monocytes | Inflammatory Autophagy Lysosomal & pahgocytosis | MAP1LC3B, RABGEF1, RELT, SESN2, TOM1, UBALD2, UPP1 | View in SCUBA |
| Mucosal-associated invariant T cell | Autophagy & Trafficking Stress | B3GNT2, BEST1, CEBPZ, CTPS1, ELOA, KANSL2, LITAF, MTFP1 +6 more | |
| Neutrophils | Inflammatory Resolution Stress | ARL5B, ATP2B1, BTG1, CREM, DDIT4, FOSL2, GPR65, JOSD1 +4 more |
About the gene
| Synonyms | BLTP4A, KIAA0404 |
|---|---|
| Chromosome | 11: 64894546-64917211 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Biological process | Autophagy, Lipid transport, Transport |
Function
Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Also regulates lipid droplets morphology and distribution within the cell.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.