ARFGAP3 — ADP ribosylation factor GTPase activating protein 3
ARFGAP3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARFGAP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector activation NFkB TCR/AP1/NFKb pathway | ADAM19, AHR, ATF5, BHLHE40, CGAS, DUSP5, ETF1, HIPK1 +23 more | View in SCUBA |
| Fibroblasts | Hypoxia Response Stress | ACSL4, AP2S1, C4orf48, EPAS1, HIF1A, IL4R, ISG20, NECTIN2 +8 more | View in SCUBA |
| Goblet cells | ER Targeting ERAD Protein processing & ER | AP3S1, ARMCX3, HM13, KCNK6, PRRC1, SELENOS, SRPRA, TMCO3 +1 more | View in SCUBA |
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AGO2, AP1G1, ATG2A, BANP, CHD1, CHD2, ERCC6 +26 more | View in SCUBA |
About the gene
| Synonyms | ARFGAP1 |
|---|---|
| Chromosome | 22: 42796502-42858106 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
| Biological process | ER-Golgi transport, Protein transport, Transport |
Function
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.