AGO2 — Argonaute RISC catalytic component 2
AGO2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGO2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR Threshold Regulation TCR Signaling | ATP8A1, AUTS2, CMIP, CNOT6L, CSNK1D, FOXO1, GSPT1, MAP3K8 +8 more | |
| Lymphatic endothelial | TBK1-JAK Immune Signaling Inflammation | ADAM17, ELL2, FNIP2, IQGAP1, JAK1, MAP4K4, NAMPT, NPC1 +6 more | View in SCUBA |
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2, ERCC6 +26 more | View in SCUBA |
| Monocytes | TREM1 Inflammatory Signaling Innate immunity | AKAP12, ATP2B1, B3GNT5, BTG1, C17orf107, CHRNE, ERRFI1, IL1R1 +6 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Quiescence T cell maturation | AUTS2, BCL6, BRD1, CSNK1D, DHCR7, FOXO1, GABPB1, GAL3ST2 +13 more |
About the gene
| Synonyms | CASC7, EIF2C2, hAGO2, LINC00980, Q10 |
|---|---|
| Chromosome | 8: 140520156-140635633 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Endonuclease, Hydrolase, Nuclease, Repressor, Ribonucleoprotein, RNA-binding |
| Biological process | Host-virus interaction, RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation |
Function
Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7- methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P- bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up- regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF- alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.