AP1G1 — Adaptor related protein complex 1 subunit gamma 1
AP1G1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AP1G1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Transcription-RNA Coupling DNA/chromatin regulation | AKNA, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, DYNC1H1, EDRF1 +26 more | |
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AGO2, ARFGAP3, ATG2A, BANP, CHD1, CHD2, ERCC6 +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear-Cytoplasmic Transport Housekeeping | CNOT1, INO80D, JARID2, NAA50, NUP98, PLEKHA2, PLEKHM1, RANBP2 +3 more |
About the gene
| Synonyms | ADTG, CLAPG1 |
|---|---|
| Chromosome | 16: 71729000-71809201 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Protein transport, Transport |
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.