FCER2 — Fc epsilon receptor II
FCER2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FCER2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B cell B cell maturation | ABCB1, ABCB4, BTLA, C1orf162, CD200, COL19A1, DSP, IGHD +15 more | View in SCUBA |
About the gene
| Synonyms | CD23, CD23A, CLEC4J, FCE2, FcepsilonRII, FCErII |
|---|---|
| Chromosome | 19: 7688758-7702146 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | IgE-binding protein, Receptor |
Function
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine- nitric oxide pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.