ABCB1 — ATP binding cassette subfamily B member 1
ABCB1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B cell B cell maturation | ABCB4, BTLA, C1orf162, CD200, COL19A1, DSP, FCER2, IGHD +15 more | View in SCUBA |
| CD4⁺ T cells | Cytokine signaling Immune regulation | ARHGEF40, AUTS2, COLQ, DSE, ERN1, GPR65, IFI44, IFNGR1 +12 more | View in SCUBA |
| Endothelial | EC Barrier Integrity Endothelial cell development | ADCY4, AQP3, ARHGAP31, CRYBG3, EPS8, FGR, FRYL, GULP1 +14 more | View in SCUBA |
| Gamma-delta T cells | Hypoxia Tissue Adaptation Tissue residence | ADAMTS17, ANKRD28, CCRL2, EPAS1, FAM3C, KLHL6, LDLRAD4, PHTF1 +10 more | |
| Innate lymphoid cells | Pyruvate Metabolism Metabolism | ADI1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2, MPC2 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Circadian Transcriptional Regulation DNA/chromatin regulation | ANKRD12, ATOSA, BMAL1, CEP250, GCC2, MIA3, MIER1, NCOA7 +2 more | |
| Natural Killer cells | Mature NK Identity Differentiation | ADAM28, ADGRG3, CCDC141, CD160, CMTM7, DZIP3, IKZF3, LZTFL1 +5 more | View in SCUBA |
About the gene
| Synonyms | ABC20, CD243, CLCS, GP170, MDR1, p-170, P-gp, PGY1 |
|---|---|
| Chromosome | 7: 87503017-87713323 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Lipid transport, Transport |
Function
Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.