DSP — Desmoplakin
DSP belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DSP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B cell B cell maturation | ABCB1, ABCB4, BTLA, C1orf162, CD200, COL19A1, FCER2, IGHD +15 more | View in SCUBA |
| Endothelial | Venous EC Identity Endothelial cell development | ALDH1A1, ALDH3A2, ASGR1, ATP9A, BMP2K, FAM107B, KIAA1522, LIMD2 +12 more | View in SCUBA |
| Enterocytes | Surface colonocyte differentiation Epithelial development | AGR3, ATP1B1, BMP3, CLDN3, KLF5, KRT20, NEURL1B, PDLIM1 +2 more | View in SCUBA |
| Goblet cells | Nuclear Architecture chromatin regulation & transcription | AK3, AKAP1, ATP1B1, ATRX, KDM5B, MYO6, NET1, NRIP1 +3 more | View in SCUBA |
| Lymphatic endothelial | Septin Cytoskeleton Cytoskeletal | AHNAK, EFCAB14, GOLGB1, PRXL2A, SEPTIN10, SEPTIN2, SEPTIN7, TPR +1 more | View in SCUBA |
About the gene
| Synonyms | DPI, DPII, KPPS2, PPKS2 |
|---|---|
| Chromosome | 6: 7541617-7586714 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
Function
Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.