CACNA1C — Calcium voltage-gated channel subunit alpha1 C
CACNA1C belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CACNA1C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Cytoskeletal trafficking kinases Cytoskeletal | AMIGO2, CDC14B, DHRS3, IQSEC1, KIF1C, LYSMD2, MAPKAPK3, PIP4K2A +6 more | View in SCUBA |
About the gene
| Synonyms | CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS |
|---|---|
| Chromosome | 12: 1970772-2697950 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Calcium channel, Calmodulin-binding, Ion channel, Voltage-gated channel |
| Biological process | Calcium transport, Host-virus interaction, Ion transport, Transport |
Function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. Pore-forming, alpha-1C subunit of the voltage- gated calcium channel that gives rise to L-type calcium currents. (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.