Cytoskeletal trafficking kinases
Gene co-expression module in Smooth muscle cells
| Category | Cytoskeletal |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Hubs converge on cytoskeletal organization and membrane trafficking: SPECC1 (actin/microtubule cytolinker), TACC1 and KIF1C (microtubule/transport), CDC14B (microtubule-stabilizing phosphatase), STK24/MST3 (STE20 kinase controlling actin and Golgi polarity), PIP4K2A (phosphoinositide signalling to actin), SNX18 and IQSEC1 (ARF-GEF, endocytic/actin remodeling), with adhesion (AMIGO2) and SMC excitability (CACNA1C) components. Distinct from the chaperone/translation neighbors but co-expressed as part of a general cell-state/trafficking axis.
Genes
AMIGO2, CACNA1C, CDC14B, DHRS3, IQSEC1, KIF1C, LYSMD2, MAPKAPK3, PIP4K2A, SNX18, SPECC1, SSBP4, STK24, TACC1, YBX3
Most correlated modules
- Actomyosin Regulation · correlation 0.74
- Vascular Matrix Secretion · correlation 0.74
- Vasoconstrictor Signaling · correlation 0.71
- Secondary Response Genes · correlation 0.69
- KLF6/ZNF24 regulators · correlation 0.66
- Pericyte Basement Membrane · correlation 0.65
- Chaperonin heat-shock · correlation 0.64
- BAG3-HSPB8 proteostasis · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.