DHRS3 — Dehydrogenase/reductase 3
DHRS3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DHRS3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Resting memory T cell Immune regulation | ANXA1, CD300A, CDC14A, CYB561, DYNLT3, IL7R, MYADM, NECTIN3 +5 more | View in SCUBA |
| Endothelial | TGF-beta ECM Remodeling ECM remodeling | ADAM10, APLP2, CCNDBP1, CYB5R3, EFEMP2, GNAS, HIPK2, MGST2 +10 more | View in SCUBA |
| Fibroblasts | Complement-producing Fibroblast Inflammatory | ANK2, C3, CLSTN3, CYP7B1, DAAM1, GUCY1A1, GUCY1B1, LPAR1 +8 more | View in SCUBA |
| Lymphatic endothelial | AhR mRNA Regulation RNA processing & translation | CYP1B1, ESAM, HNRNPDL, HNRNPH1, LIF, SDC4, TIPARP, TPBG +3 more | View in SCUBA |
| Monocytes | Secretory Vesicle Trafficking Vesicular traficking | ABHD17C, CTNNBL1, FAM20C, HMGA1, NRIP1, PCBP3, SEMA3F, STX1A +1 more | View in SCUBA |
| Smooth muscle cells | Cytoskeletal trafficking kinases Cytoskeletal | AMIGO2, CACNA1C, CDC14B, IQSEC1, KIF1C, LYSMD2, MAPKAPK3, PIP4K2A +6 more | View in SCUBA |
About the gene
| Synonyms | RDH17, retSDR1, Rsdr1, SDR1, SDR16C1 |
|---|---|
| Chromosome | 1: 12567910-12618210 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Catalyzes the reduction of all-trans-retinal to all-trans- retinol in the presence of NADPH
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.