IQSEC1 — IQ motif and Sec7 domain ArfGEF 1
IQSEC1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IQSEC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | AGTPBP1, AHNAK, ATP2B4, DIAPH1, FLNA, ITCH, ITGA4, OGDH +8 more | |
| Smooth muscle cells | Cytoskeletal trafficking kinases Cytoskeletal | AMIGO2, CACNA1C, CDC14B, DHRS3, KIF1C, LYSMD2, MAPKAPK3, PIP4K2A +6 more | View in SCUBA |
About the gene
| Synonyms | ARF-GEP100, BRAG2, GEP100, KIAA0763 |
|---|---|
| Chromosome | 3: 12897043-13283281 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin. Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.