AMIGO2 — Adhesion molecule with Ig like domain 2
AMIGO2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AMIGO2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Neural-crest Fibroblast Developmental | C1orf54, CENPW, DCLK1, FLRT2, FOXP2, IGFBP4, KIAA0408, MAOB +8 more | View in SCUBA |
| Smooth muscle cells | Cytoskeletal trafficking kinases Cytoskeletal | CACNA1C, CDC14B, DHRS3, IQSEC1, KIF1C, LYSMD2, MAPKAPK3, PIP4K2A +6 more | View in SCUBA |
About the gene
| Synonyms | ALI1, DEGA |
|---|---|
| Chromosome | 12: 47075707-47079959 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Cell adhesion |
Function
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.