PIP4K2A — Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
PIP4K2A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIP4K2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin-Splicing Regulation DNA/chromatin regulation | ANKRD11, BOD1L1, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MED10 +13 more | |
| Hematopoietic progenitor cells | Replication Stress Response Cell cycle | CENPU, DNAJC9, EIF2AK1, HLTF, MRPL52, POLE2, SLC12A6, TLN1 +2 more | |
| Macrophages | DNA Damage Response Stress | APAF1, ARHGAP35, ATP11C, ATR, CDC42SE2, CENATAC, CEP192, CEP85L +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | STAT4 T cell Identity T cell maturation | ATF7IP, CAMK4, CBLB, CD96, CELF2, DENND4A, IKZF1, JMJD1C +7 more | |
| Smooth muscle cells | Cytoskeletal trafficking kinases Cytoskeletal | AMIGO2, CACNA1C, CDC14B, DHRS3, IQSEC1, KIF1C, LYSMD2, MAPKAPK3 +6 more | View in SCUBA |
About the gene
| Synonyms | PIP5K2A, PIP5KIIA, PIP5KIIalpha |
|---|---|
| Chromosome | 10: 22534854-22714578 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Lipid metabolism |
Function
Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level. In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism. PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.