CASP5 — Caspase 5
CASP5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CASP5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Inflammatory cell death Inflammation | CASP10, CASP8, NAMPT, NOS2, PLAC8, PLSCR1, TMC5 | View in SCUBA |
| Monocytes | Inflammasome Activation Innate immunity | AIM2, APOBEC3G, ARID5B, BATF3, BST2, CD47, CNDP2, CYSTM1 +4 more | View in SCUBA |
About the gene
| Synonyms | ICE(rel)III |
|---|---|
| Chromosome | 11: 104994235-105023168 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
| Biological process | Apoptosis |
Function
Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin- D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. Also mediates cleavage and maturation of IL18. Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.