Inflammatory cell death
Gene co-expression module in Enterocytes
| Category | Inflammation |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
CASP8, CASP10, CASP5, NOS2, PLAC8, PLSCR1 and NAMPT are all IFN-gamma/inflammatory-induced genes in colonocytes. NOS2 is a hallmark of inflamed colon epithelium. The caspases indicate death-receptor and inflammasome (pyroptotic) priming. TMC5 is an epithelial gene co-induced in colitis.
Genes
CASP10, CASP5, CASP8, NAMPT, NOS2, PLAC8, PLSCR1, TMC5
Most correlated modules
- STAT3/JNK signaling · correlation 0.89
- Epithelial NF-kB response · correlation 0.87
- IFN-gamma response · correlation 0.85
- IFN-gamma STAT1 signaling · correlation 0.83
- Colonocyte terminal differentiation · correlation 0.82
- NF-kB epithelial activation · correlation 0.81
- Basal adhesion remodeling · correlation 0.81
- DUOX2 oxidative defense · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.