SCUBA

APOL6 — Apolipoprotein L6

APOL6 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

APOL6's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsInterferon Response
Anti-viral
ARL6IP5, BAX, GBP4, GBP5, IFI16, IQGAP1, IRF9, MYH9 +4 moreView in SCUBA
EndothelialIFN-gamma Response
Inflammation
APOL2, BATF2, CARD16, CASP1, CD40, CXCL10, CXCL11, CXCL9 +18 moreView in SCUBA
EnterocytesIFN-gamma response
Inflammation
BIRC3, GBP1, GBP2, IRF1, NUB1, PARP14, PARP9, RNF213 +2 moreView in SCUBA
FibroblastsType I Interferon
Inflammatory
BATF2, CXCL10, GBP1, IFI44L, IFIT2, IFIT3, ISG15, MX1 +6 moreView in SCUBA
Gamma-delta T cellsMetabolic-Translational Coupling
RNA processing & translation
ARCN1, ARGLU1, DCAF12, DDX23, EIF2S1, EIF4G1, FHOD1, GMPPB +20 more
Goblet cellsMHC Class I Antigen Presentation
Immune function
APOL1, B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, IFI27 +4 moreView in SCUBA
Innate lymphoid cellsIFN-gamma Response
Inflammation
B3GALT5, DST, ELK3, GBP2, GBP4, GBP5, GOLGA8A, HLA-DRB1 +16 moreView in SCUBA
MacrophagesAntiviral ISG Response
Antiviral
ADAR, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1, IFIH1 +29 moreView in SCUBA
MonocytesIFN-gamma Response
Antiviral
APOL2, CXCL10, ETV7, GBP1, GBP4, GBP5, IFIH1, ISG15 +6 moreView in SCUBA
Mucosal-associated invariant T cellT cell Homeostasis
T cell maturation
CD40LG, CNDP2, FAM118A, FCMR, GPR171, IFIH1, IL7R, ISG20 +19 more
Natural Killer cellsIFN-stimulated NK
Inflammation
AKNA, ATM, CTSC, ITGAL, MBP, MXD1, PILRB, PTPRC +4 moreView in SCUBA

About the gene

SynonymsAPOL-VI, APOLVI
Chromosome22: 35648446-35668404
Predicted locationMembrane
Essential geneNo
Protein classPredicted membrane proteins
Biological processLipid transport, Transport

Function

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.