IFN-γ Antiviral Response
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by canonical IFN-γ-stimulated genes: GBP1/GBP2 (guanylate-binding proteins), TAP1/TAP2 (antigen processing/transport), PARP9/PARP14 (ISGs), APOL1/APOL2/APOL6 (IFN-induced apolipoproteins), RNF213 (ISG E3 ligase), IFI35, DTX3L, NUB1. HLA-F adds MHC-I antigen presentation. CFB (complement factor B) and CASP5 (inflammasome caspase) extend the innate immune response. TYMP is IFN-inducible. This is the most coherent and strongly IFN-γ-driven module in the batch, with near-universal inf_colono enrichment and the highest delta_inflammation score.
Genes
Most correlated modules
- Inflammasome Pyroptosis · correlation 0.93
- IFN-γ Metabolic Reprogramming · correlation 0.91
- Basement Membrane Remodeling · correlation 0.89
- Hypoxia-Inflammatory Reprogramming · correlation 0.88
- TNF Apoptosis Resistance · correlation 0.87
- TGF-β Chromatin Regulation · correlation 0.87
- Inflamed Barrier Remodeling · correlation 0.85
- Type I Interferon Response · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.