APOL1 — Apolipoprotein L1
APOL1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APOL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Lipid Metabolism Metabolite transfer | ACSL4, CDK2AP2, COPS8, GBE1, GOLM1, MAPRE1, NPC1, PDLIM7 +5 more | View in SCUBA |
| Glial cells | IFN-gamma Effector Program Inflammation | APOL2, GBP1, IDO1, IFI44L, IL18BP, IL32, LAP3, ODF3B +5 more | View in SCUBA |
| Goblet cells | MHC Class I Antigen Presentation Immune function | APOL6, B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, IFI27 +4 more | View in SCUBA |
| Monocytes | Immunoproteasome Antigen Processing Innate immunity | APOL4, FBXO6, IFI27, IFI35, LGALS3BP, PSMB8, PSMB9, PSME1 +5 more | View in SCUBA |
About the gene
| Synonyms | APOL |
|---|---|
| Chromosome | 22: 36253071-36267530 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Biological process | Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport |
Function
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.