CBLN2 — Cerebellin 2 precursor
CBLN2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CBLN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Lamina Propria ECM ECM production | ADAMTS7, ADGRL4, ANGPTL6, BMP2, CYTL1, DHRS7C, FAM135B, FBN2 +14 more | View in SCUBA |
About the gene
| Chromosome | 18: 72536680-72638521 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
Function
Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for long-term maintenance but not establishment of excitatory synapses. Functions as part of a trans-synaptic complex by binding to postsynaptic GRID1 and presynaptic neurexins. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2- GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.