ADAMTS7 — ADAM metallopeptidase with thrombospondin type 1 motif 7
ADAMTS7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAMTS7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ECM Fibrotic Remodeling ECM remodeling | ANGPTL2, CD276, CETP, COL18A1, COLGALT1, DDI2, ERO1A, LBH +7 more | View in SCUBA |
| Fibroblasts | Lamina Propria ECM ECM production | ADGRL4, ANGPTL6, BMP2, CBLN2, CYTL1, DHRS7C, FAM135B, FBN2 +14 more | View in SCUBA |
About the gene
| Synonyms | ADAM-TS7, DKFZp434H204 |
|---|---|
| Chromosome | 15: 78759206-78811464 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
Metalloprotease. Was previously shown to degrade COMP. However, a later study found no activity against COMP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.