Lamina Propria ECM
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include FBN2 (fibrillin-2, elastic fiber ECM), LAMA5 (laminin alpha-5, basement membrane), LAMC3 (laminin gamma-3), ITGA8 (integrin alpha-8, ECM receptor), ADAMTS7 (ADAMTS metalloprotease, ECM remodeling), CYTL1 (stromal cytokine-like factor), LPAR3 (LPA receptor - connecting to M115's ENPP2/LPA axis), BMP2 (connecting to M133's BMP5), NRG1 (neuregulin), NPY (neuropeptide Y), GRIN2A, and KCNK3. The dominant theme is ECM structural production and remodeling (FBN2, LAMA5, LAMC3, ITGA8, ADAMTS7) combined with neural-type signaling genes (NPY, NRG1, GRIN2A, KCNK3) characteristic of intestinal lamina propria fibroblasts. The module is suppressed in inflammation and restored in remission, consistent with a homeostatic ECM-producing fibroblast state. The LPA and BMP connections to neighboring modules reinforce a shared quiescent fibroblast program.
Genes
ADAMTS7, ADGRL4, ANGPTL6, BMP2, CBLN2, CYTL1, DHRS7C, FAM135B, FBN2, GRIN2A, ITGA8, KCNK3, LAMA5, LAMC3, LANCL2, LPAR3, NDST4, NPY, NQO1, NRG1, PTCHD1, SLC4A4, SLITRK6
Most correlated modules
- Intestinal Fibroblast Identity · correlation 0.83
- BMP-Wnt Fibroblast Program · correlation 0.81
- Wnt-BMP Fibroblast · correlation 0.79
- WNT-modulating Fibroblast · correlation 0.76
- Telocyte Identity Program · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.