BMP2 — Bone morphogenetic protein 2
BMP2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BMP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Chemokine Response Chemotaxis | CCL2, CEBPB, CEBPD, CNKSR3, CXCL1, CXCL2, CXCL3, CXCL8 +14 more | View in SCUBA |
| Fibroblasts | Lamina Propria ECM ECM production | ADAMTS7, ADGRL4, ANGPTL6, CBLN2, CYTL1, DHRS7C, FAM135B, FBN2 +14 more | View in SCUBA |
| Lymphatic endothelial | NF-κB Negative Feedback Inflammation | C2CD4B, ICAM1, IRF8, KLF6, MAFF, NFIL3, NFKBIA, PRNP +4 more | View in SCUBA |
| Smooth muscle cells | ER-Golgi Secretory Protein processing & ER | ARL2, ATP2A2, CD46, LAMB2, PLXND1, RNASEH2C, SPTB, YIF1A | View in SCUBA |
About the gene
| Synonyms | BMP2A |
|---|---|
| Chromosome | 20: 6767686-6780246 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins |
| Molecular function | Cytokine, Developmental protein, Growth factor |
| Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Function
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.