CCDC66 — Coiled-coil domain containing 66
CCDC66 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCDC66's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | IL6-STAT3 Signaling Intercellular communication | ARID5A, ARL6IP1, AZIN1, CDC40, CEMIP2, CHD1, CSNK1D, EIF4G2 +13 more | View in SCUBA |
About the gene
| Synonyms | DKFZp686C0433 |
|---|---|
| Chromosome | 3: 56557161-56621837 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Cilium biogenesis/degradation |
Function
Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites. Required for the assembly of signaling-competent cilia with proper structure and length. Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex. Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation. Plays two important roles during cell division. First, is required for mitotic progression via regulation of spindle assembly, organization and orientation, levels of spindle microtubules (MTs), kinetochore-fiber integrity, and chromosome alignment. Second, functions during cytokinesis in part by regulating assembly and organization of central spindle and midbody MTs. Plays a role in retina morphogenesis and/or homeostasis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.