BCL11B — BAF chromatin remodeling complex subunit BCL11B
BCL11B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCL11B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B, FAM78A +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Transcriptional Identity T cell maturation | AAK1, ANKRD36B, ATG16L2, EMB, ETS1, GOLGA8B, HNRNPUL2, LSM14A +8 more |
About the gene
| Synonyms | CTIP-2, CTIP2, hRIT1-alpha, SMARCM2, ZNF856B |
|---|---|
| Chromosome | 14: 99169287-99272197 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.