BAIAP2 — BAR/IMD domain containing adaptor protein 2
BAIAP2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BAIAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Pol II Transcription Regulation DNA/chromatin regulation | ABHD5, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1, EIF4A1 +28 more | View in SCUBA |
| Endothelial | Inflammatory EC Activation Inflammation | ANGPT2, B3GNT5, EPHA2, GMFB, HIC1, HMOX1, JUP, LPIN2 +6 more | View in SCUBA |
| Fibroblasts | Integrated Stress Response Stress | ATF4, DNAJB6, EIF4A3, EIF5, FSCN1, HSP90AB1, HSPD1, HSPE1 +9 more | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BCL2L11, BEND4, BIRC3, CBL +24 more | |
| Macrophages | Lipid-Sensing Transcriptional Lipid metabolism | ANKLE2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2, FBRS +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tc17 / MAIT17 Tc17 program | AHR, CA10, CCR9, GFPT2, HIC1, IL17A, IL2, ITGA1 +5 more |
About the gene
| Synonyms | BAP2, IRSp53, WAML |
|---|---|
| Chromosome | 17: 81035122-81117434 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.